This is one of many reasons why electrolyte balance is so so important.
Insulin oscillations - Wikipedia, the free encyclopediaQuote
The insulin concentration in blood increases after meals and gradually returns to basal levels during 1-2 hours. However, the basal insulin level is not stable. It oscillates with a regular period of 3-6 min. After a meal the amplitude of these oscillations increases but the periodicity remains constant. [1] The oscillations are believed to be important for insulin sensitivity by preventing downregulation of insulin receptors in target cells. [1] Such down regulation underlies insulin resistance, which is common in type 2 diabetes. It would therefore be advantageous to administer insulin to diabetic patients in a manner mimicking the natural oscillations. [1] The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islet of Langerhans.
For correct synchronization cells need to have appropriate concentrations of calcium ions in the cell, which requires all of the electrolyte minerals to be in balance.


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