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  1. Default Reversing Glycation

    #1
    Eccentrics Anonymous

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    I have heard that nobody yet knows how to reverse glycation. Have any of you heard of ways to do just this?

    Some things I found on the net:
    "For instance, calcium pyruvate and carnosine not only appear to help prevent this reaction, but also stimulate proteolysis, or the degradation of glycated proteins."

    "Alpha lipoic acid:
    Alpha-lipoic acid may function in four ways to slow skin aging. First, it is a potent antioxidant. Second, it helps maintain the health of the mitochondria, the powerhouses of the cell. When the mitochondria are metabolically compromised, skin cells cannot perform youthful repair functions. Third, alpha-lipoic acid helps turn off an inflammatory messenger known as nuclear factor kappa B that can severely damage skin. Last, alpha-lipoic acid activates a collagen-regulating factor known as AP-1 that turns on enzymes that digest glycation-damaged collagen. As we age, the accumulation of glycated collagen crosslinks can result in visible skin again. Alpha-lipoic acid has shown a unique mechanism of facilitating the enzymatic removal of glycated-damaged collagen. The new Rejuvenex® contains a potent concentration of alpha-lipoic acid encased in a QuSome® vehicle to enable it to penetrate deep into the skin."

    "Nutritional products that act as cross-linking (AGE) inhibitors include carnosine, aminoguanidine, metformin, acarbose, and pyridoxamine. Cross-linking breakers, or re-versers, are not yet commercially available, but thiazolium products such as ALT-711 (dimethyl-3-phenacyl-thiazolium chloride) and PTB (dimethyl-phenacyl-thiazolium bromide) are being tested with good results. Q As people age falls are all too common."
    - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements

    "The best way to deal with glycation (you can't totally stop it, as it's part of the aging process) is to minimize it and slow it down by eating less sugars/carbs in general, esp fructose, which is the most glycating of sugars because of the way the liver processes it, and to take supplements that are anti-glycation. These supplements include:

    L-Carnosine
    Benfotiamine (a form of B1)
    Trans-Resveratrol (not regular resveratrol)
    Alpha-Lipoic Acid
    Pyridoxamin (a form of B6)"

    I also found that yac extract (derived from the herb mugwort) has glycation inhibiting properties.

    More on glycation:
    MECHANISMS OF AGING
  2.  
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    Interesting thing glycation, nice post.

    Calcium pyruvate reverses glycation very well, and it can be well prevented by superoxide dismutase (SOD), Alpha-Lipoic Acid, and avoiding excessive nitric oxide output and the enzymes that increase it like nitric oxide synthase.

    Superoxide dismutase, an important antioxidant, is the bodies best protective agent against glycation - glycation occurs mostly when excessive blood glucose gets shifted to the sorbitol/aldose-reductase pathway (sometimes called the polyol pathway), and SOD is good at limiting the overspill.

    SOD can be naturally increased with a good intake of dark green leafy veg and cruciferous veg like broccoli, cabbage etc. Adequate copper and Vitamin C is also important for SOD synthesis, and a high intake of these combined with ensuring that carb intake is mostly lower GI will act in a suitably preventative way against non ezymatic glycation.
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    Quote Quote
    Originally Posted by Loki View Post
    Calcium pyruvate reverses glycation very wel
    Thanks a lot for the info. Any studies that show the above to be true?
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    Quote Quote
    Originally Posted by Rayza View Post
    Thanks a lot for the info. Any studies that show the above to be true?
    It's actually the Pyruvate that has the positive effects on AGEs and not calcium pyruvate itself which can just be thought of as a substance to deliver the pyruvate which it does very effectively.

    Quote Quote
    Non-enzymatic glycation of lens proteins and haemoglobin-inhibition by pyruvate: an in-vivo study

    Devamanoharan PS, Ali AH, Varma SD.

    Department of Ophthalmology, University of Maryland, Baltimore 21201, USA.
    Abstract

    AIM: Previous studies have demonstrated that pyruvate can prevent protein glycation and oxidative stress under in-vitro conditions. The aim of this study was to examine the in-vivo effectiveness of this metabolite against glycation of lens crystallins and haemoglobin in galactosemic rats.

    METHODS: Sprague-Dawley rats were maintained on a 30% or 50% galactose-containing diet in the absence or presence of 2% or 5% pyruvate in food and water, respectively. The animals were killed subsequently and the extent of glycation of lens crystallins and haemoglobin was determined using an affinity column chromatograpic technique.

    RESULTS: Maintenance of rats on the high galactose diet resulted in a significant increase in glycation of both the proteins. The increase was faster and more substantial in the animals maintained on the 50% galactose diet than that in the animals fed a 30% galactose diet. The increase in the latter was also very significant. Supplementation with pyruvate inhibited the process.

    CONCLUSION: The inhibition is attributable to a competitive binding of pyruvate to the protein NH2 groups as well as to the antioxidant effect of the compound. The studies therefore suggest that this and other alpha-keto-acids may be physiologically useful in minimizing glycation and oxidative stress induced tissue pathology by the hyperglycaemic conditions, such as diabetes and galactosemia. The results are also considered pharmacologically significant.
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    Incidentially, pyruvate is synthesised during the breakdown of glucose for energy during exercise via glycolysis, and as a result exercise limits the glycating potential of fast carbs consumed to fuel exercise.

    Fast carbs at other times do not cause such a rate of glycolysis if at all, so in that circumstance can contribute to glycation, but during exercise the pyruvate acts protectively
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    Loki; how much calcium p do you recommend I take for the purposes of breaking some of those glycation bonds?
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    I remember reading something about the durg ALT-711's ability to reverse advanced glycation end-products in a paper outlining a treatment for renal failure in diabetics with the compound.

    http://en.wikipedia.org/wiki/Alagebrium

    Seems like an interesting thing to look into if you're really interested in the reversal of accumulated AGE's. A brief look on google comes up with people using it for the same purpose.
    Using this code with your first order will make you a ripped machine. Use with the up most of care!
    MP2484
    *may or may not make you a ripped machine...infact it most certainly wont.

    Disclaimer: All posts on these forums are for information and discussion purposes only and solely the views of the forum member who posted. No posts constitute or replace medical advice. Any information should be considered in regard to specific circumstances. All advice is followed at your own risk and should be followed up with your own research or doctors advice.

    sendos is a Supplements & Training and Diet Moderator.
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    http://www.fasebj.org/cgi/content/full/17/12/1762

    there's the paper if your interested.
    Using this code with your first order will make you a ripped machine. Use with the up most of care!
    MP2484
    *may or may not make you a ripped machine...infact it most certainly wont.

    Disclaimer: All posts on these forums are for information and discussion purposes only and solely the views of the forum member who posted. No posts constitute or replace medical advice. Any information should be considered in regard to specific circumstances. All advice is followed at your own risk and should be followed up with your own research or doctors advice.

    sendos is a Supplements & Training and Diet Moderator.
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    Quote Quote
    Originally Posted by Rayza View Post
    Loki; how much calcium p do you recommend I take for the purposes of breaking some of those glycation bonds?
    Eeek, not qualified to give that info but will research further and come back on it.
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    I want to start a little phase in which I focus on breaking down this glycation as best I can.

    Loki; would you recommend simply taking a lot of calcium pyruvate? Or would you use a variety of things such as carnosine, acetyl l-cartinine, alpha lipoic acid and DMAE?

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