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  1. Default Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal.

    #1 30-07-2010 08:15 PM
    Gareth83
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    Neurosci Lett. 2010 Aug 2;479(3):201-5. Epub 2010 May 24.
    Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal.

    Hammett ST, Wall MB, Edwards TC, Smith AT.

    Department of Psychology, Royal Holloway University of London, Egham Hill, Egham, Surrey TW20 0EX, UK. s.hammett@rhul.ac.uk
    Abstract

    Creatine monohydrate is an organic acid that plays a key role in ATP re-synthesis. Creatine levels in the human brain vary considerably and dietary supplementation has been found to enhance cognitive performance in healthy individuals. To explore the possibility that the fMRI Blood Oxygen Level Dependent (BOLD) response is influenced by creatine levels, BOLD responses to visual stimuli were measured in visual cortex before and after a week of creatine administration in healthy human volunteers. The magnitude of the BOLD response decreased by 16% following creatine supplementation of a similar dose to that previously shown to increase cerebral levels of phosphocreatine. We also confirmed that cognitive performance (memory span) is increased. These changes were not found in a placebo group. Possible mechanisms of BOLD change are considered. The results offer potential for insight into the coupling between neural activity and the BOLD response and the more immediate possibility of accounting for an important source of variability during fMRI analysis in clinical studies and other investigations where between-subjects variance is an issue. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

    PMID: 20570601 [PubMed - in process]
    Dietary supplementation of creatine monohydrate re... [Neurosci Lett. 2010] - PubMed result

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    #2 23-08-2010 04:15 PM
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    What a lovely paper....Full text? :P
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    #3 23-08-2010 08:36 PM
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    When you eat the foods your body is made for (Paleo foods) in a framework that your body is made for (feast-fast, such as IF), it all works beautifully.
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    #4 23-08-2010 10:38 PM
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    I disagree. I think it increases the human fMRI BOLD signal and reduces the human fMRI Italic signal.

    Apologies for the horrific joke.

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    #5 23-08-2010 10:46 PM
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    Hi Tom!!
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    #6 24-08-2010 12:17 AM
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    good to see the jokes are still the same!
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    #7 24-08-2010 11:03 PM
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    #8 24-08-2010 11:11 PM
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    of course!
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