Charles: It's within parameters. One practice that a lot of people listening to this call have, that you've spoken out against, is the whole idea of having a post-workout shake. I'd love for you to elaborate on that a little bit. Obviously, the theory behind this is you're replenishing the muscle that loss glycogen. There's different theories about this, whether you take protein or protein and carb, and so forth. But what is your approach for guys who are lifting, post-workout?
Art: I think the replenishment, you will replenish more readily. But the problem is 2 things happen: you're taking in foods that create an insulin spike, so that shuts down the growth hormone response that you induced in your workout. That's very important.
Insulin is basically antagonistic to growth hormone. So, the high glycemic load, the protein shake, even protein elicits an insulin response. So, you're shutting down one of the adaptive hormones that's intending to increase through the workout, and that's growth hormones.
The other thing is that you're shutting down gene expression, because muscle gene expression occurs in response to signals you've created. One is the intensity of the workout and then mitogen-activated protein kinases send signals to the muscles to begin rebuilding. And 2, that gene expression takes place best in a glycogen-depleted muscle.
So, if you replenish the glycogen immediately or quickly, you shut down gene expression that's remodeling the muscle that you intended to train.
Charles: You're aware that you're the only person out there talking about this subject, right? Really! I?ve just never heard this from anybody else out there. I'm well-versed in all of the thinkers in this field, so very interesting.
Art: Again, gene expression is so much. And it's all an acute expression. It doesn't go on indefinitely, because the glycogen eventually remodels or repletes in the muscle. But you do that by burning fat and other substrates. So, why put that stuff in there.
Charles: So, unless I'm misreading you, you think that insulin spikes are not worth the down-side in any context. Is that right?
Art: I really don't. All of the hormones tend to be released in a rather pulsing fashion, in a spiky fashion. Insulin spikes, particularly large ones, kill more receptors or damage or downturn or down-regulate receptor sensitivity more than does a lower but chronic amount. It's like life is built up with lots of shocks, and the big shocks will be the huge print on your genetic composition and your gene expression and on your hormone profiles and the sensitivities to those hormones.
So, for example, a transitory shock of insulin after a Thanksgiving meal, followed by a good dessert and maybe preceded by wine and followed by a liquor, that mark's left on your metabolism for a very long time.
Charles: Really? Very interesting. I've never heard it put that way.
Art: It's like we know now that your worst sunburn is the one that's most likely to give you skin cancer.
Charles: That's true. That's true.
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