Tocotrienols are great.
Quote
some research suggests tocotrienols are more potent in their anti-oxidation and anti-cancer effect than the common forms of tocopherol due to significant differences in chemical structure.Quote
Tocotrienols show antioxidant properties considerably superior to dl-α-Tocopherol in clinical and experimental studies due to their better distribution in the fatty layers of the cell membrane. The tocotrienol unsaturated side chain allows for more efficient penetration into saturated fatty layers of the brain and liver. In addition to the free radical scavenging effect, the antioxidant function of tocotrienols is also associated with lowering tumor formation, DNA damage and cell damage.Quote
A study showed that tocotrienols are the components of vitamin E responsible for growth inhibition in human breast cancer cells in vitro as well as in vivo through estrogen-independent mechanisms. Tocotrienols can also affect cell homeostasis, possibly independently of their antioxidant activity.[3] Anti-cancer effects of α- and γ-tocotrienol have been reported, although δ-tocotrienol was verified to be the most effective tocotrienol in inducing apoptosis (cell death) in estrogen-responsive and estrogen-nonresponsive human breast cancer cells. A daily dose of 30 - 50 mg mixture of α- and γ-tocotrienols can reduce breast cancer risk, and a treatment plan for breast cancer should use higher dosage.Quote
Investigation of the antiproliferative effect of tocotrienols in PC3 and LNCaP prostate cancer cells suggests that the transformation of vitamin E to CEHC is mostly a detoxification mechanism, useful to maintain the malignant properties of prostate cancer cells.[4] However, recent research suggested that γ-tocotrienol was most potent in suppressing prostate cancer cell proliferation, and that the antiproliferative effect of γ-tocotrienol act through multiple-signalling pathways (NF-B, EGF-R and Id family proteins). In addition, the same study demonstrated the anti-invasion and chemosensitisation effect of γ-tocotrienol against PCa cells.Quote
The development of new cholesterol-lowering agents has been given increasing attention by pharmaceutical companies due to the strong relationship between cholesterol and atherosclerosis. Tocotrienols, especially δ- and γ-tocotrienols, were shown to be effective nutritional agents to treat high cholesterol in recent research programs. In particular, γ-tocotrienol appears to act on a specific enzyme called 3-hydroxy-3-methylglutaryl-coenzyme and suppresses the production of this enzyme, resulting in less cholesterol being manufactured by liver cells.[6] However, studies have demonstrated that the presence of dietary alpha-tocopherol may interfere with Gamma-tocotrienol's ability to lower cholesterol[7]. Moreover, research has found that alpha-tocopherol may decrease the absorption of tocotrienolAny idea how much the palm oil contains?Quote
nvestigation of the intake of antioxidants for its ability to prevent type 2 diabetes shows that vitamin E intake was significantly associated with a reduced risk of type 2 diabetes. The relative risk (RR) of type 2 diabetes between the extreme quartiles of the intake was 0.69 (95% CI 0.51-0.94, P for trend=0.003). Intakes of alpha-tocopherol, gamma-tocopherol, delta-tocopherol, and beta-tocotrienol were inversely related to a risk of type 2 diabetes. Thus the development of type 2 diabetes may be reduced by the intake of antioxidants in the diet.


LinkBack URL
About LinkBacks
Reply With Quote








Bookmarks