mega cissus MEGA WOW

[cheef]

only been using for 10days or so but damn its awesome i look fuller feel strong and look leaner bigger

some article on it for those noobs

issus quadrangularis

Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. It was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. Modern research has shed light on Cissus' ability to speed bone healing by showing it acts as a glucocorticoid antagonist (1,2). Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing, it has been postulated that Cissus possesses anabolic and/or androgenic properties (1,3). In addition to speeding the remodeling process of the healing bone, Cissus also leads to a much faster increase in bone tensile strength. In clinical trials Cissus has led to a fracture healing time on the order of 55 to 33 percent of that of controls. That cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakend by treatment with cortisol, and upon administration of Cissus extract the cortisol induced weakening was halted, and the healing process begun.

While the increased rate of bone healing may be of great significance to persons suffering from chronic diseases like osteoporosis (4), the antiglucocorticoid properties of Cissus are likely of much more interest to the average bodybuilder or athlete, since endogenous glucocorticoids, particularly cortisol, are not only catabolic to bone, but catabolize muscle tissue as well. Numerous studies over the years have suggested that glucorticoids, including the body's endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis (5). This pathway of tissue breakdown is important for removing damaged and non-functional proteins. However, when it is overactive during periods of elevated cortisol (e.g disease states, stress, and overtraining) excess amounts of normal tissue are broken down as well. By exerting an anabolic, antiglucorticoid effect cissus helps preserve muscle tissue during times of physical and emotional stress.

Although the bulk of the research on Cissus centers around bone healing, the possibility exists that Cissus may act to improve bone healing it may improve the healing rate of connective tissue in general, including tendons. If this is the case it would be of great benefit to bodybuilders and athletes.

Besides the above-mentioned properties of Cissus, the plant is also rich in the vitamins/antioxidants vitamin C and beta-carotene. As analyzed, Cissus quadrangularis contained ascorbic acid 479 mg, and carotene 267 units per 100g of freshly prepared paste in addition to calcium oxalate (6).

The typical recommended daily dosage of Cissus extract is between 100 and 500 mg, depending on the concentration of the extract and the severity of symptoms. For the powder of the dried plant, the Ayurvedic texts recommend a dosage of 3 to 6 grams to accelerate fracture healing. Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So not only is Cissus efficacious, it is also quite safe, in either the dried powder form or the commercially available extract.

Cissus also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis constitutes one of the ingredients of an Ayurvedic preparation, `Laksha Gogglu', which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins.

[cheef]

Cissus quadrangularis, aka Veldt Grape and commonly referred just as Cissus, is a perennial climber used on Ayurvedic medicine to speed recovery from bone fracture, relieve gastric disorders, as an analgesic and an anti-inflammatory. Currently there are more features associated to Cissus quadrangularis like anti-glucocorticoid, anti-catabolic, anti-lipase, anti-oxidant and anti-bacterial properties, making it not only a good choice for those who are looking for a supplement to relieve joint pain and connective tissue problems but also for those who are interested in a supplement capable of giving help in the process of increasing muscle mass and/or reducing body fat.

There are several active substances in Cissus responsible for its benefits: phytosterols (like beta-sitosterol), vitamin C, calcium, carotenes (like provitamin A), amyrin (a specific saponin), amyrone and flavonoids (quercetin). Some of the features of Cissus are not yet fully understood, so there may be more active substances yet to be discovered in Cissus.

A couple of properties showed by Cissus are similar with Resveratrol, another great supplement. Both exhibit anti-oxidant properties capable of increasing AST and ALT values as well as being natural anti-inflammatories. In the case of Cissus the analgesic activity is achieved on both neurogenic pain as well as peripheral (inflammatory) pain. Analgesic properties on neurogenic pain are due to central analgesic activity, like opioids. Peripheral analgesic activity (anti-inflammatory activity) is believed to be due to COX-2 inhibition, also like opioids and NSAIDs, though there was no protein synthesis inhibition and no gastric disorders unlike some NSAIDs (Cissus it is capable of relieving gastric disorders). Along with analgesic and anti-inflammatory properties, Cissus has also bone and connective tissue healing properties which make it a good option to use when there's a need not only for pain relief but also for an increased healing.

Cortisol is a steroid hormone that belongs to the glucocorticoid class of steroid hormones and is capable of inhibiting protein synthesis and stimulate amino acid degradation (among other things). For this reason, excessive cortisol can be conterproductive to those seeking to increase muscle mass. Moreover, cortisol rises with stress and after strenuous exercise, which are situations that athletes have to deal with frequently. Cissus is capable of interacting with the glucocorticoid receptor (GR) by binding to it and acting as a GR antagonist, avoiding cortisol to bind to the GR and thus reducing cortisol's negative effects and positively influencing muscle mass development.

[Alpal2005]

Since earlier this year (about march) I have had a weak wrist from falling on it whilst playing football. (i can hear the jokes already...) Since then if i flex my wrist too far towards my under or over forearm i experience pain. This has also resulted in me being unable to do press ups on my hands. It feels like possible tendon damage, it may go for a while but then the slightest pressure with a flexed wrist and the pain returns. you get the idea.

Would mega cissus be a good thing to take in order to help my wrist heal? Cos it is driving me mad!

[Alpal2005]

Sounds like it is worth a go then LH! MP says on the mega C. page that dosage is two caps per day. Did you find this sufficient? Or did you take a higher dose?

[AlexTemper]

I'd say to be carefull when using Cissus and to definately cycle. While it's excellent for repair it can at the same time mask potential damage and you'll only be aware once you stop using. There are many cases of injuries being worse than before cissus use due to it masking the pain whilst the area continued to be damaged.

Regarding Cortisol it's worth reiterating part of the quote Cheef has posted:

Quote

Cissus is capable of interacting with the glucocorticoid receptor (GR) by binding to it and acting as a GR antagonist, avoiding cortisol to bind to the GR and thus reducing cortisol's negative effects and positively influencing muscle mass development.

What this means is that it can reduce the effects of Cortisol on the body but not reduce actual Cortisol levels in the body.

Having said all of the above it is an excellent supplement to mega dose with, more for it's anti-catabolic/anti cortisol effects.

[Luffers]

Cheef, are you talking about MP's stuff or did you get it elsewhere? MP's stuff is only 6% Ketosterone, stronger stuff is available.

[cheef]

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Cheef, are you talking about MP's stuff or did you get it elsewhere? MP's stuff is only 6% Ketosterone, stronger stuff is available.

mps and about 3g a day mite bump to 6tho

[Alpal2005]

Cheers LH! My wrist injury sounds no way near as extreme as others on this forum! so I reckon i will start light with dosage. Despite some of the negative aspects highlighted by Alex, Seems like a great product! Just need the buggers to get back in stock!

[AlexTemper]

General 2g-3g of active ingredient and up to 6g for decent joint repair but in terms of how many caps this will depend on keto %.

[AlexTemper]

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The product page for the 50% Ketosterone capsules says 400mg of 'Cissus Quadrangularis' per capsule.

So how many caps needed from the figs you give above do you reckon please ?
2g = 2000mg (?), 2000 divided by 400 = 5 caps
3g = ............ 7.5 caps
6g = ............ 15 caps ? (Or have I got my sums wrong ?)

2g would be 10 caps as each cap (400mg) is 50% keto (200mg) of active ingredient so you'd need 4g of total powder to get 2g of active ingredient:

4g / 400mg gives 10 caps.